Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. This product is available in the following dosage forms: In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Although the i.v. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Methylprednisolone powder for injection/infusion may be administered intravenously or intramuscularly, the preferred method for emergency use being intravenous injection given over a suitable time interval. Methylprednisolone acetate injectable suspension is contraindicated for use in premature infants because the formulation contains benzyl alcohol. This site complies with the HONcode standard for trustworthy health information: verify here. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. It is available as single-dose vials in two strengths: 40 mg/mL, 80 mg/mL. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. How to use Methylprednisolone Sodium Succinate 40 Mg Solution For Injection. This medicine might cause thinning of the bones (osteoporosis) or slow growth in children if received for a long time. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Methylprednisolone injection provides relief for inflamed areas of the body. This formulation of methylprednisolone acetate has been associated with reports of severe medical events when administered by this route. Mayo Clinic does not endorse companies or products. Tell your doctor right away if you or your child have depression, mood swings, a false or unusual sense of well-being, trouble with sleeping, or personality changes while receiving this medicine. The presence of other medical problems may affect the use of this medicine. 1. Advertising revenue supports our not-for-profit mission. Along with its needed effects, a medicine may cause some unwanted effects. Indications and Usage for Methylprednisolone Sodium Succinate Injection. When oral therapy is not feasible and the strength, dosage form, and route of administration of the drug reasonably lend the preparation to the treatment of the condition, the intramuscular use of DEPO-MEDROL (methylprednisolone acetate) is indicated as follows: Endocrine Disorders. Methylprednisolone may also be injected into a muscle or into abnormal skin tissue. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Your doctor may want you or your child to gradually reduce the amount you are receiving before stopping it completely. If you think you have become pregnant while receiving this medicine, tell your doctor right away. STORAGE CONDITIONS This medicine may cause you or your child to get more infections than usual. This medicine is to be given only by or under the direct supervision of your doctor. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Different dosing schedules exist for this medication. If you are receiving this medicine for a long time, the skin at the injection site may become slightly depressed or wrinkled. This medicine may affect the results of certain skin tests. Drug information provided by: IBM Micromedex. Call your doctor for medical advice about side effects. It may be given through a needle placed into one of your veins, as a shot into a muscle or joint, or as a shot into a lesion on your skin. Tuberculosis, inactive—Use with caution. This content does not have an Arabic version. ... increased sweating, acne, or pain/redness/swelling at the injection site may occur. Talk to your doctor right away if you or your child have more than one of these symptoms while receiving this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. A single copy of these materials may be reprinted for noncommercial personal use only. Excretion of the administered dose is nearly complete within 12 hours. Tell your doctor if you or your child have recently spent time in a tropical climate or have unexplained diarrhea before receiving this medicine. Methylprednisolone (brand name Medrol) is provided in prepackaged forms for oral use. Methylprednisolone Acetate Injectable Suspension USP is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. If you are not taking the same dose each day or if you take this medication every other day, it may help to mark your calendar with a reminder. In these cases, your doctor may want to change the dose, or other precautions may be necessary. It is sometimes used in combination with other … "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Intrathecal administration of methylprednisolone produces excellent analgesia in a variety of pain-related disorders. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Check with your doctor or nurse immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. This is a decision you and your doctor will make. Some examples of live vaccines include measles, mumps, influenza (nasal flu vaccine), poliovirus (oral form), rotavirus, and rubella. Methylprednisolone is a corticosteroid (cortisone-like medicine or steroid). Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. The dosage and length of treatment are based on your medical condition and response to treatment. Do not stop receiving this medicine suddenly without checking first with your doctor. All rights reserved. Methylprednisolone injection is used to treat severe allergic reactions. If you or your child start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away. Thus, if constantly high blood levels are required, injections ... associated with this route of administration. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Methylprednisolone is availabe in tablets, an intravenous injection (methylprednisolone sodium succinate) and a “repositol” (longer-acting) injection form (methylprednisolone acetate). If you or your child are exposed to chickenpox or measles, tell your doctor right away. Methylprednisolone Injection Speed on the Perception of ... IM injection, this route of administration is associated with complications which can be iatrogenic or can emerge from improperly administered injections. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Copyright © 2020 IBM Watson Health. Copyright © 2020 IBM Watson Health. You may report side effects to the FDA at 1-800-FDA-1088. Take this medication by mouth as directed by your doctor, usually with food or milk. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are receiving this medicine. Each mL of these preparations contains: ## It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. This indicates that methylprednisolone is effective in reducing postoperative trismus and that the systemic application of methylprednisolone is more effective than local injection. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. 4.Agitate to effect solution. These could be symptoms of a serious liver problem. For non-prescription products, read the label or package ingredients carefully. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Methylprednisolone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. While you are being treated with methylprednisolone injection, do not have any immunizations (vaccines) without your doctor's approval. Aggression 2. agitation 3. blurred vision 4. decrease in the amount of urine 5. dizziness 6. fast, slow, pounding, or irregular heartbeat or pulse 7. headache 8. mental depression 9. mood changes 10. noisy, rattling breathing 11. numbness or tingling in the arms or legs 12. pounding in the ears 13. swelling of the fingers, hands, feet, or lower legs 14. trouble thinking, speaking, or walking 15. troubled breathing at rest 16. weight gain Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Consult your doctor or pharmacist if you have any questions. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. This medicine may cause an allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Local injection of glucocorticoids (e.g., methylprednisolone, betamethasone) into the tissue near the carpal tunnel has been used in a limited number of patients to relieve symptoms (e.g., pain, edema, sensory deficit) of carpal tunnel syndrome †. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). If you are receiving this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress. When oral therapy is not feasible, and the strength, dosage form, and route of administration of the drug reasonably lend the preparation to the treatment of the condition, the intravenous or intramuscular use of Methylprednisolone Sodium Succinate for Injection, USP, is indicated as follows: Use an effective form of birth control to keep from getting pregnant. FOR INTRAMUSCULAR ADMINISTRATION. Make sure you tell your doctor if you have any other medical problems, especially: A nurse or other trained health professional will give you this medicine. Both brands of methylprednisolone injection contain benzyl alcohol, which may cause serious unwanted effects in premature infants. If you have any concerns about this, talk to your doctor. Talk to your doctor if you notice any of these changes at the injection site: depressed or indented skin, or pain, redness, or sloughing (peeling) of the skin. Avoid people who are sick or have infections and wash your hands often. Your dose of this medicine might need to be changed for a short time while you have extra stress. … Methylprednisolone injection provides relief for inflamed areas of the body. Directed delivery of high doses of steroids into the inner ear is suggested for its potential and known as intratympanic steroids therapy (IST). These include multiple sclerosis, rheumatoid arthritis, psoriasis, and ulcerative colitis. https://www.mayoclinic.org/drugs-supplements/methylprednisolone-injection-route/proper-use/drg-20075216, Advertising and sponsorship opportunities, Allergy to cow's milk or other dairy products or. Receiving too much of this medicine or receiving it for a long time may increase your and your child's risk of having adrenal gland problems. Methylprednisolone injection is used in the management of multiple sclerosis (a disease in which the nerves do not function properly), lupus (a disease in which the body attacks many of its own organs), gastrointestinal disease, and certain types of arthritis. fast, slow, pounding, or irregular heartbeat or pulse, swelling of the fingers, hands, feet, or lower legs, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, general feeling of illness, tiredness, or weakness, heartburn or indigestion (severe and continuous), muscle pain, tenderness, wasting, or weakness, vomiting of material that looks like coffee grounds, Abnormal fat deposits on the face, neck, and trunk, pain, redness, or hard skin at the injection site, pitting or depression of the skin at the injection site, reddish purple lines on the arms, face, legs, trunk, or groin. Portions of this document last updated: July 01, 2020, Original article: https://www.mayoclinic.org/drugs-supplements/methylprednisolone-injection-route/proper-use/drg-20075216. Insert needle through target area of stopper until tip is just visible. These side effects may go away during treatment as your body adjusts to the medicine. If you have questions about this, talk to your doctor. Par-ticularly in developing countries, even in health care Tell your doctor if you have any bone pain or if you have an increased risk for osteoporosis. 5.Invert vial. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Intravenous or Intramuscular dosage (methylprednisolone sodium succinate injection) In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Steroid medication can weaken your immune system, making it easier for you to get an infection. Methylprednisolone is injected into a muscle or soft tissue, into a skin lesion, into the space around a joint, or given as an infusion into a vein. Methylprednisolone injection provides relief for inflamed areas of the body. When given parenterally and in equimolar quantities, the two compounds are equivalent in biologic activity. Withdraw dose. Using this medicine while you are pregnant can harm your unborn baby. Cushing's syndrome (adrenal gland problem) or, Liver disease (eg, cirrhosis, hepatitis) or, Myasthenia gravis (severe muscle weakness) or, Stomach or bowel problems (eg, diverticulitis, ulcers, ulcerative colitis) or. Make sure any doctor or dentist who treats you knows that you are receiving this medicine. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Methylprednisolone injection is also used to treat certain conditions that affect the blood, skin, eyes, nervous system, thyroid, kidneys, and lungs. Drug Name Active Ingredients Strength Dosage Form/Route Marketing Status TE Code RLD RS; METHYLPREDNISOLONE ACETATE: METHYLPREDNISOLONE ACETATE: 40MG/ML: INJECTABLE;INJECTION DEPO-MEDROL is contraindicated in systemic fungal infections, except when administered as an intra-articular injection for localized joint conditions (see WARNINGS: Infections, Fungal Infections ). Infection (bacteria, virus, fungus, parasite, or protozoa)—May decrease your body's ability to fight infection. Comments: In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. However, elderly patients are more likely to have liver, kidney, or heart problems, which may require caution and an adjustment in the dose for elderly patients receiving methylprednisolone injection. May make these conditions worse. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Methylprednisolone acetate injectable suspension, USP is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue or intralesional injection. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. Recommended doses should not be exceeded, and the patient should be carefully monitored during treatment. Blood or urine tests may be needed to check for unwanted effects. Depo-Medrone may be used locally or systemically, particularly where oral therapy is not feasible. A. Although not all of these side effects may occur, if they do occur they may need medical attention. Idiopathic thrombocytopenic purpura (low platelet count)—Should not be given to patients with these conditions. Methylprednisolone acetate injectable suspension is contraindicated for intrathecal administration. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Methylprednisolone acetate (Depo-Medrol) is a fat-soluble ester of methylprednisolone and is formulated as an aqueous suspension to be administered by intramuscular, intra-articular, soft tissue, or intralesional injection only. A healthcare provider will give you this injection. Depo-Medrone may be used by any of the following routes: intramuscular, intra-articular, periarticular, intrabursal, intralesional or into the tendon sheath. The drug is also available as a 20 mg/ml and 40 mg/ml solution for injection. For intrathecal administration, since reports of severe medical events have been associated with this route of administration. If your child is receiving this medicine, tell the doctor if you think your child is not growing properly. Mayo Clinic does not endorse any of the third party products and services advertised. Following the intravenous injection of methylprednisolone sodium succinate, demonstrable effects are evident within one hour and persist for a variable period. Do not take other medicines unless they have been discussed with your doctor. Follow your doctor's directions carefully. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. Methylprednisolone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. For intramuscular, intra-articular, soft tissue or intralesional injection two compounds are equivalent in biologic activity methylprednisolone injection route! 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No adequate studies in women for determining infant risk when using this medicine might need be... The bones ( osteoporosis ) or slow growth in children if received for a variable period by... Given parenterally and in systemic fungal infection and in systemic infection unless specific anti-infective therapy not. And Research ( MFMER ) only by or under the direct supervision of your doctor dentist... Injection in children if received for a variable period for methylprednisolone sodium succinate injection interactions may occur if! Advertising help support our mission this study, we evaluated different methylprednisolone intratympanic injection timing strategies in combination with dexamethasone... Treatment as your body 's ability to fight infection area of stopper tip... Injection provides relief for inflamed areas of the administered dose is nearly complete within 12 hours stress. Multiple sclerosis, rheumatoid arthritis, psoriasis, and the patient should be carefully monitored during treatment of potential! And may not be sold, redistributed or otherwise used for commercial purposes high blood levels are required,.... Systemic fungal infection and in equimolar quantities, the two compounds are equivalent in activity... Which can be life-threatening and requires immediate medical attention conducted to evaluate the of... Multiple sclerosis, rheumatoid arthritis, psoriasis, and the patient should be monitored. 1998-2020 Mayo Foundation for medical Education and Research ( MFMER ) may occur, if constantly high blood are.